We show how metagenomic analysis of the human gut antibiotic resistome, compared across large populations and against environmental or agricultural resistomes, suggests a strong anthropogenic cause behind increasing antibiotic resistance in bacteria. This area has been the subject of intense and polarized debate driven by economic and political concerns; therefore such recently available insights address an important need. We derive and compare antibiotic resistomes of human gut microbes from 832 individuals from ten different countries. We observe and describe significant differences (...) between samples from these countries in the gut resistance potential, in line with expectations from antibiotic usage and exposure in medical and food production contexts. Our results imply roles for both of these sources in increased resistance among pathogens in recent history. In contrast, other available metadata such as age, body mass index, sex, or health status have little effect on the antibiotic resistance potential of human gut microbes.Also watch the Video Abstract. (shrink)

The growing importance of the cryptocurrency phenomenon has raised concerns about the ethical implications of a hypothetical widespread use of these new forms of digital money. In this paper, we undertake an ethical assessment of cryptocurrencies drawing upon two specific ethical theories: private property ethics and utilitarianism. Particularly, we focus on three distinctive aspects. First, we examine the advantages and disadvantages of cryptocurrencies vis‐à‐vis central bank fiat money. Second, we analyze cryptocurrencies as facilitators of tax evasion and the ethical implications (...) arising therefrom. Finally, we explore the use of cryptocurrencies for nefarious consumption. We conclude that, were cryptocurrencies to become widespread media of exchange, governments capacity to undertake monetary, fiscal, and drug policy would be undermined. We argue that this would be an ethically desirable outcome from both a private‐property‐rights and a utilitarian perspective since it would force governments to reduce their size and scope in these three areas. (shrink)

The growing importance of the cryptocurrency phenomenon has raised concerns about the ethical implications of a hypothetical widespread use of these new forms of digital money. In this paper, we undertake an ethical assessment of cryptocurrencies drawing upon two specific ethical theories: private property ethics and utilitarianism. Particularly, we focus on three distinctive aspects. First, we examine the advantages and disadvantages of cryptocurrencies vis‐à‐vis central bank fiat money. Second, we analyze cryptocurrencies as facilitators of tax evasion and the ethical implications (...) arising therefrom. Finally, we explore the use of cryptocurrencies for nefarious consumption. We conclude that, were cryptocurrencies to become widespread media of exchange, governments capacity to undertake monetary, fiscal, and drug policy would be undermined. We argue that this would be an ethically desirable outcome from both a private‐property‐rights and a utilitarian perspective since it would force governments to reduce their size and scope in these three areas. (shrink)

En esta ponencia nos proponemos mostrar que ciertas tesis o consensos recibidos sobre pseudoprocesos causales , procesos cuya característica prominente parece ser superar la velocidad de la luz, deben ser cuestionados o seriamente modificados. Dos de dichos consensos son, primero, que los PSP deberían ser tratados simplemente como "basura espacio-temporal" y, segundo, que ellos no cumplen, aparte de permitir aislar procesos causales genuinos, ninguna función epistémica o metodológica en la descripción de cualquier estado físico, en particular, al interior de la (...) relatividad especial . Para ello, apelaremos a procedimientos de medición física bien conocidos tanto en física clásica como en RE. Como consecuencia de lo anterior, argumentamos que, una vez que los PSP son integrados en toda la escena física, se revela que ellos juegan un rol fundamental y más complejo en la física experimental de lo que hasta ahora se ha pensado. In this paper we show that some received contentions about causal pseudo processes , processes of which the most salient aspect seems to be travelling faster than the speed of light, must be rejected o seriously modified. Two of such contentions are, first, that PSPs should be considered just "spatiotemporal junk" and, second, that they do not meet, besides allowing us to isolate proper genuine causal processes, any other epistemic or methodological role in the description of a physical state of affair, in particular, in a special relativity setting. In order to do that, we are going to appeal to physical measure procedures, well known both in classic and relativistic physics. As a consequence of that, we contend that, once PSPs are integrated into the whole physical scenario, a fundamental and more complex role for them in experimental physics is revealed. (shrink)

This paper analyses the gender pay determinants between top and lower level of Portuguese employees. A relatively large data pool, for 2003, covering business functions hitherto neglected, sheds a new light into the factors that lead to the earnings of men and women. Our analysis combines human capital with internal-labour-markets theories. Our findings allow the identification of jobsegregation as one important source of the gender pay gap. Moreover, they confirm that earnings are determined by different factors and suggest a reasonable (...) opportunity for women to combine career and family. (shrink)

We draw on the behavioral agency model to explore the ethical consequences of CEO equity incentives. We argue that CEOs are more concerned with funding pension plans when they have more to gain from their stock options yet will increasingly underfund employee pension funds as their current option wealth increases. Our findings reveal that both effects hold when the CEO has greater power (also occupying board chair) over firm decision making. Our study suggests that there is an ethical dimension to (...) equity incentives, given they are intended to align CEO interests with shareholders, yet potentially incentivize CEO behaviors with adverse consequences for employees. Insights from our findings provide boards and regulators with behavioral levers to protect employee well-being in the context of pension funding. (shrink)

To encourage corporations to contribute positively to the environment in which they operate, voluntary self-regulatory codes (SRC) have been enacted and refined over the past 15 years. Two of the most prominent are the United Nations Global Compact and the Global Reporting Initiative. In this paper, we explore the impact of different stakeholders' pressures on the selection of strategic choices to join SRCs. Our results show that corporations react differently to different sets of stakeholder pressures and that the SRC selection (...) depends on the type and intensiveness of the stakeholder pressures as well as the resources at hand to respond to those pressures. Our contribution offers a more specific and finely variegated analysis of firmstakeholder interactions. (shrink)

As COVID-19 emerged as a phenomenon of the total environment, and despite the intertwined and complex relationships that make humanity an organic part of the Bio- and Geospheres, the majority of our responses to it have been corrective in character, with few or no consideration for unintended consequences which bring about further vulnerability to unanticipated global events. Tackling COVID-19 entails a systemic and precautionary approach to human-nature relations, which we frame as regaining diversity in the Geo-, Bio-, and Anthropospheres. Its (...) implementation requires nothing short of an overhaul in the way we interact with and build knowledge from natural and social environments. Hence, we discuss the urgency of shifting from current to precautionary approaches to COVID-19 and look, through the lens of diversity, at the anticipated benefits in four systems crucially affecting and affected by the pandemic: health, land, knowledge and innovation. Our reflections offer a glimpse of the sort of changes needed, from pursuing planetary health and creating more harmonious forms of land use to providing a multi-level platform for other ways of knowing/understanding and turning innovation into a source of global public goods. These exemplary initiatives introduce and solidify systemic thinking in policymaking and move priorities from reaction-based strategies to precautionary frameworks. (shrink)

Espirales que nos rondan: La llave de la confianzaVivimos con la sensación de estar perdiendo algo muy esencial. No alcanzamos a conversar en profundidad con la persona más significativa, llegamos tarde a los amaneceres y a los crepúsculos, cerramos rápido el periódico saturado de crímenes y de noticias de dolorosos enfrentamientos, nos sentimos secos, fantasmales, después de ver el programa frívolo de la televisión o el mensaje comercial que encontramos en el computador. Una vivencia de de..

This paper adopts a cognitive linguistic framework to explore the influence of spatial and social factors on the use of Spanish demonstratives esta ‘this’ and esa ‘that’. Twenty adult Spanish speakers in Monterrey, Mexico, were asked questions prompting the selection of puzzle pieces for placement in a 25-piece puzzle located in the shared space between the participant and an addressee. Although participants were not explicitly instructed to produce demonstratives, the need to identify specific puzzle pieces naturally elicited a total of (...) 523 tokens of esta and esa. Analyses of the distribution of esta versus esa show that demonstratives are not used in a categorical manner to mark differences in physical space. Although participants tended to produce proximal esta for referents near the speaker, both esta and esa were used for referents further from the speaker and closer to the addressee. Participants’ demonstrative selection was also influenced by interaction type: intersubjective misalignment between speakers promoted the use of proximal esta, whereas intersubjective alignment promoted the use of distal esa. These results support the view that nominal grounding is an intersubjective activity. Physical and social factors jointly shape speakers’ construal of the developing co-constructed communicative event as a whole, leading to increasingly variable usage of demonstratives as the referent is more distant both spatially and intersubjectively from the speaker. (shrink)

O artigo pretende expor uma visão crítica sobre a teoria da secularização defendida por Carl Schmitt e sobre a reflexão de Martin Heidegger a respeito da metafísica do sujeito. Mais precisamente, nosso foco recai criticamente sobre a equivalência entre niilismo e autolegislação humana presente na obra de ambos os autores. Nosso objetivo é apreender tais formulações em duas dimensões imbricadas: uma delas, teórico-filosófica, e a outra, histórica. Em seguida, buscamos colocá-las em perspectiva crítica tendo em vista especialmente a reflexão desenvolvida (...) por Hans Blumenberg e alguns de seus comentaristas. Pretendemos proceder a contraposição entre (i) a noção de autolegislação humana como niilismo e (ii) a legitimidade do espaço do simbólico. Sem negar a crítica ao racionalismo limitante, que inclui a superação do sujeito cartesiano, a abordagem que defendemos legitima a dimensão de mediação entre o tempo da vida e tempo do mundo, mediação que pode se dar tanto pela elaboração científica quanto pelo pensamento filosófico ou religioso. Por fim, buscamos apontar a relação entre o espaço simbólico e a superação da noção de mímesis como imitação ou simples adequação. Palavras-chave: Autolegislação humana. Niilismo. Simbólico. Mímesis .The article aims to expose a critical view about the theory of secularization advocated by Carl Schmitt and also about Martin Heidegger's reflection on metaphysics of the subject. More precisely, our focus rests critically upon the equivalence between nihilism and human self-legislation present in the work of both authors. Our goal is to apprehend such formulations in two imbricated dimensions: one, theoretical and philosophical, and the other historical. Then, we seek to put both in a critical perspective, in special the reflection developed by Hans Blumenberg and some of his commentators. We intend to make the counterposition between (i) the notion of human self-legislation as nihilism and (ii) the legitimacy of the symbolic space. Without denying the critique of the limiting rationalism, which includes the overcoming the Cartesian subject, the approach we advocate legitimates the dimension of mediation between life-time and world-time, mediation that can occur either by scientific elaboration or by philosophical or religious thought. Finally, we seek to point out the relationship between the symbolic space and the overcoming on the notion of mimesis as an imitation or a mere adequacy. Keywords: Human self-legislation. Nihilism. Symbolic. Mímesis. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Castro, Rodrigo y Chamorro, Emmanuel (eds.) (2021)Para una crítica del neoliberalismo: Foucault y Nacimiento de la Biopolítica Madrid: Lengua de Trapo, 538 p. ISBN 978-84-8381-265-5.

Resenha do livro de Ceticismo e Naturalismo: algumas variedades, de P. F. Strawson. Traduçáo de Jaimir Conte. Sáo Leopoldo: Editora Unisinos, 2008, 114 páginas.

What does it mean to consider the world of AI through a Christian lens? Rapid developments in AI continue to reshape society, raising new ethical questions and challenging our understanding of the human person. Encountering Artificial Intelligence draws on Pope Francis’ discussion of a culture of encounter and broader themes in Catholic social thought in order to examine how current AI applications affect human relationships in various social spheres and offers concrete recommendations for better implementation. The document also explores questions (...) regarding personhood, consciousness, and the kinds of relationships humans might have with even the most advanced AI. Through these discussions, this book investigates the theoretical and practical challenges to interpersonal encounter raised by the age of AI. (AI Research Group for the Centre for Digital Culture of the Dicastery of Culture and Education of the Holy See). (shrink)

ABSTRACTThe social content of affective stimuli has been proposed as having an influence on cognitive processing and behaviour. This research was aimed, therefore, at studying whether automatic exogenous attention demanded by affective pictures was related to their social value. We hypothesised that affective social pictures would capture attention to a greater extent than non-social affective stimuli. For this purpose, we recorded event-related potentials in a sample of 24 participants engaged in a digit categorisation task. Distracters were affective pictures varying in (...) social content, in addition to affective valence and arousal, which appeared in the background during the task. Our data revealed that pictures depicting high social content captured greater automatic attention than other pictures, as reflected by the greater amplitude and shorter latency of anterior P2, and anterior and posterior N2 components of the ERPs. In addition, social content also provoked greater allocation of processing resour... (shrink)

In preparation for the development of a rapid tissue donation programme, we surveyed healthcare providers in our institution about knowledge and attitudes related to RTD with lung cancer patients. A 31-item web based survey was developed collecting data on demographics, knowledge and attitudes about RTD. The survey contained three items measuring participants’ knowledge about RTD, five items assessing attitudes towards RTD recruitment and six items assessing HCPs’ level of agreement with factors influencing decisions to discuss RTD. Response options were presented (...) on a 5-point Likert scale. Ninety-one HCPs participated in the study. 66% indicated they had never heard of RTD prior to the survey, 78% rated knowledge of RTD as none or limited and 95.6% reported not having ethical or religious concerns about discussing RTD with patients. The majority were either not comfortable or not sure if they felt comfortable discussing RTD with cancer patients . 56.1% indicated their knowledge of RTD would play an integral role in their decision to discuss RTD with patients. 71.4% reported concerns with RTD discussion and the emotional state of the patient. Physicians and nurses play an important role in initiating conversations about recruitment and donation to research that can ultimately influence uptake. Increasing HCP knowledge about RTD is a necessary step towards building an RTD programme. Our study provides important information about characteristics associated with low levels of knowledge and practice related to RTD where additional education and training may be warranted. (shrink)

Resenha do livro de BARROS, Brasil Fernandes de. _A busca de Kardec_: fé ou razão. Curitiba: CRV, 2022. 232 p. ISBN 978-65-251-3981-4.

In this paper I present reasons for us to accept the hypothesis that suspended judgment has correctness conditions, just like beliefs do. Roughly put, the idea is that suspended judgment about p is correct when both p and ¬p might be true in view of certain facts that characterize the subject’s situation. The reasons to accept that hypothesis are broadly theoretical ones: it adds unifying power to our epistemological theories, it delivers good and conservative consequences, and it allows us to (...) assess processes of reasoning involving attitudes of suspended judgment. (shrink)